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Atopic dermatitis is a chronic, pruritic, inflammatory skin disease that occurs most frequently in children, but also a great number of adults. Clinical features of atopic dermatitis include skin dryness, erythema, oozing and crusting, and lichenification. While many patients with mild or moderate disease can be managed with topical and traditional treatments, there are unmet needs for chronic and severe cases. New and developing therapies such as small molecule inhibitors and biologic hold promise for real advances in management of this complex disease.